Fine Chemical industry ndi gawo lazachuma lopanga mankhwala abwino m'makampani opanga mankhwala, omwe ndi osiyana ndi mankhwala opangidwa ndi mankhwala kapena mankhwala ambiri. Makhalidwe ake oyambirira ndi kupanga mankhwala apamwamba kwambiri, amitundu yambiri, apadera kapena ogwiritsidwa ntchito bwino pazachuma cha padziko lonse ndi moyo wa anthu omwe ali ndi teknoloji yapamwamba komanso yatsopano. maiko ena otukuka motsatizana asintha njira zoyendetsera makampani opanga mankhwala kukhala makampani abwino a mankhwala, ndipo kufulumizitsa chitukuko chamakampani opanga mankhwala kwakhala njira yapadziko lonse lapansi. zowonjezera chakudya, zowonjezera chakudya, zomatira, surfactants, mankhwala ochizira madzi, mankhwala achikopa, mafuta mafuta, mankhwala amagetsi, papermaking mankhwala ndi zina zoposa 50.

Mankhwala apakatikati amatanthawuza mankhwala apakatikati omwe amapangidwa popanga kaphatikizidwe ka mankhwala amankhwala ndipo amakhala azinthu zabwino zamankhwala. Mankhwala ophatikizika amatha kugawidwa m'magulu ophatikizira maantibayotiki, antipyretic ndi analgesic intermediates, intermediates mtima, ndi anticancer intermediates malinga ndi minda yawo. za mankhwala intermediates ndi zofunika mankhwala zopangira mafakitale, pamene makampani kunsi kwa nyanja ndi mankhwala API ndi kukonzekera makampani.Monga katundu wochuluka, mtengo wa zinthu zofunika mankhwala zopangira zimasinthasintha kwambiri, zomwe zimakhudza mwachindunji mtengo kupanga mabizinesi.Pharmaceutical intermediates ndi zogawika mu pulayimale wapakatikati ndi zapamwamba intermediates, pulayimale wapakatikati chifukwa cha zovuta kupanga luso si mkulu, mitengo ndi otsika, ndipo anawonjezera mtengo mu oversupply zinthu, intermediates apamwamba ndi chachikulu wapakatikati anachita mankhwala, poyerekeza ndi choyambirira wapakatikati, dongosolo zovuta, basi. sitepe imodzi kapena pang'ono pokonzekera zinthu zamtengo wapatali zowonjezedwa kunsi kwa mtsinje, mulingo wake wa malire ndi wapamwamba kuposa malire amakampani apakatikati. unyolo wokhala ndi mpikisano wothamanga kwambiri komanso kuthamanga kwamitengo, komanso kusinthasintha kwamitengo ya zinthu zopangira mankhwala kumakhudza kwambiri iwo. kunyamula zopanga zapamwamba zokhala ndi luso lapamwamba kwambiri ndikusunga ubale wolimba ndi makampani amitundu yosiyanasiyana, kotero kusinthasintha kwamitengo yazinthu zopangira sikumakhudza kwambiri iwo.Non-gmp intermediates ndi GMP intermediates akhoza kugawidwa malinga ndi kuchuluka kwa chikoka pa chomaliza. API quality.Non-gmp intermediate imatanthawuza mankhwala apakatikati asanayambe API; GMP yapakatikati imatanthawuza mankhwala apakatikati opangidwa pansi pa zofunikira za GMP, ndiko kuti, chinthu chomwe chimapangidwa pambuyo pa API poyambira zinthu, panthawi ya API synthesis. masitepe, ndipo amakumana ndi kusintha kwina kwa mamolekyulu kapena kukonzedwa asanakhale API.

Chiwongola dzanja chachiwiri cha patent chidzapitiliza kulimbikitsa kufunikira kwa olowera kumtunda
Makampani apakatikati amankhwala amasinthasintha chifukwa cha kuchuluka kwa makampani opanga mankhwala otsika, ndipo nthawi yake imakhala yogwirizana ndi yamakampani opanga mankhwala. kuzunguliridwa kwa mankhwala atsopano pamsika;Zinthu zamkati makamaka zimanena za kutetezedwa kwa patent kwa mankhwala opangidwa mwatsopano.Liwiro la kuvomerezedwa kwamankhwala kwatsopano ndi mabungwe owongolera mankhwala monga FDA kulinso ndi chikoka pamakampani. Pamene nthawi yovomerezeka ya mankhwala atsopano ndi chiwerengero cha mankhwala ovomerezeka atsopano ndi abwino kwa makampani opanga mankhwala, kufunikira kwa ntchito zopangira mankhwala kudzapangidwa. Zaka khumi zapitazi, kuchuluka kwa kuvomereza kwamankhwala kwatsopano kupitilira kupangitsa kuti anthu azigwira ntchito kumtunda, motero kuthandizira makampani kuti akhalebe olimba. Chitetezo cha patent cha mankhwala opangidwa ndiukadaulo chikatha, mankhwala opangidwa ndi generic adzakhala bwino kwambiri, ndipo opanga apakatikati amasangalalabe ndi kukula kwakukulu kwa kufunikira kwakanthawi kochepa. Malinga ndi ziwerengero za Evaluate, akuti kuyambira 2017 mpaka 2022, padzakhala 194 biliyoni ya msika wa mankhwala omwe akukumana ndi kutha kwa patent, yomwe ndi yachiwiri pachimake kuyambira 2012.

Zosintha m'zaka zaposachedwa, ndikukula komanso kapangidwe kamankhwala kazovuta, kafukufuku watsopano wamankhwala ndi chiwongolero chachitukuko chachepa, kukwera kwachangu kwa kafukufuku watsopano wamankhwala ndi mtengo wa chitukuko cha McKinsey ku Nat. Rev. DrugDiscov. "Otchulidwa, mu 2006-2011, kafukufuku watsopano wa mankhwala ndi chitukuko cha chipambano ndi 7.5% yokha, kuchokera ku 2012 mpaka 2014, chifukwa cha macromolecules zamoyo zabwino kusankha bwino ndi kawopsedwe otsika wa kuphonya mtunda (mankhwala mu siteji ya chitukuko mochedwa, ndiko kuti, kuchokera gawo lachipatala la III ku mndandanda wovomerezeka uli ndi chipambano cha 74%), kafukufuku wa mankhwala ndi chitukuko chiwongoladzanja chonse chikuwonjezeka pang'ono, komabe n'zovuta kubwereranso ku 16.40% mu 90 s. Mtengo wolembera bwino watsopano mankhwala adakwera kuchokera kwa ife $1.188 biliyoni mu 2010 kufika kwa ife $2.18 biliyoni mu 2018, pafupifupi kuwirikiza kawiri. Pakalipano, mlingo wobwereranso wa mankhwala atsopano ukupitirirabe kuchepa. Mu 2018, zimphona zapadziko lonse za TOP12 zamankhwala zidangobweza 1.9% pazachuma pakufufuza ndi chitukuko.

Kuwonjezeka kwa ndalama za r & d ndi kuchepa kwa kubwerera kwa r & d kwabweretsa mavuto aakulu kwa makampani opanga mankhwala, kotero iwo adzasankha kutulutsa njira zopangira mabizinesi a CMO mtsogolomo kuti achepetse ndalama. Malingana ndi ChemicalWeekly, ndondomeko yopangira zinthu imakhala pafupifupi 30% ya mtengo wonse wa mankhwala oyambirira.Mchitidwe wa CMO/CDMO ungathandize makampani opanga mankhwala kuchepetsa mtengo wamtengo wapatali wa katundu wokhazikika, kupanga bwino, ntchito za anthu, certification, audit ndi zina. ndi 12-15%.Kuonjezera apo, KUKHALA kwa CMO / CDMO mode kungathandize makampani opanga mankhwala kuti apititse patsogolo zokolola, kufupikitsa masitonkeni ndi kuonjezera chitetezo, chomwe chingapulumutse nthawi yopangira makonda, kufupikitsa r & d cycle of mankhwala opangidwa mwaluso, kufulumizitsa kutsatsa kwamankhwala mwachangu, ndikupangitsa makampani opanga mankhwala kukhala ndi phindu lochulukirapo.

Mabizinesi aku China CMO ali ndi zabwino monga kutsika mtengo kwazinthu zopangira ndi ntchito, njira zosinthika ndiukadaulo, ndi zina zambiri, komanso kusamutsa makampani apadziko lonse a CMO kupita ku China kumalimbikitsa kukulirakulira kwa msika waku China wa CMO.Msika wapadziko lonse wa CMO/CDMO ukuyembekezeka. kutipitilila $102.5 biliyoni mu 2021, ndi kukula kwapawiri pafupifupi 12.73% mu 2017-2021, malinga ndi zoneneratu South.

Padziko lonse lapansi msika wamankhwala wabwino mu 2014, mankhwala ndi ma intermediates ake, mankhwala ophera tizilombo ndi ophatikizika ake ndi mafakitale awiri apamwamba amakampani opanga mankhwala abwino, omwe amawerengera 69% ndi 10% motsatana.China ili ndi mafakitale amphamvu a petrochemical ndi kuchuluka kwakukulu opanga mankhwala opangira mankhwala, omwe apanga magulu am'mafakitale, akupanga mitundu yambiri yamitundu yaiwisi ndi zida zothandizira zomwe zimafunikira popanga mankhwala apamwamba kwambiri omwe amapezeka ku China, kuwongolera magwiridwe antchito ndikuchepetsa mtengo wonse. wathunthu mafakitale dongosolo, zomwe zimapangitsa mtengo wa zida mankhwala, yomanga ndi unsembe ku China kutali kwambiri kuposa mayiko otukuka kapena ngakhale mayiko ambiri osauka, motero kuchepetsa ndalama ndi kupanga cost.In Komanso, China ali ndi chiwerengero chachikulu cha okhoza ndi otsika- akatswiri opanga mankhwala ndi mafakitale ogwira ntchito.Intermediates makampani ku China apangidwa kuchokera ku kafukufuku wa sayansi ndi chitukuko mpaka kupanga ndi malonda a dongosolo lathunthu la dongosolo lathunthu, kupanga mankhwala a mankhwala opangira mankhwala ndi zopangira zopangira zofunikira zingathe kupanga seti yathunthu, ochepa okha. kufunika kuitanitsa, akhoza kutulutsa intermediates mankhwala, intermediates mankhwala ndi magulu ena 36 akuluakulu, kuposa 40000 mitundu ya intermediates, pali zinthu zambiri wapakatikati akwaniritsa chiwerengero chachikulu cha zotumiza kunja, wapakatikati zogulitsa kunja matani oposa 5 miliyoni pachaka, wakhala dziko. zazikulu zapakatikati kupanga ndi kunja.

China pharmaceutical intermediates makampani akhala otukuka kwambiri kuyambira 2000.Pa nthawi imeneyo, makampani mankhwala m'mayiko otukuka chidwi kwambiri ndi kafukufuku mankhwala ndi chitukuko ndi chitukuko msika monga pachimake mpikisano wawo ndipo inapita patsogolo kusamutsa intermediates ndi yogwira kaphatikizidwe mankhwala ku mayiko osauka. ndi otsika cost.Therefore, China mankhwala intermediates makampani kutenga mwayi uwu kupeza chitukuko chabwino kwambiri.Pambuyo pa zaka zoposa khumi chitukuko mosalekeza, China wakhala yofunika yapakatikati kupanga m'munsi mu gawo lonse la ntchito mu makampani mankhwala mothandizidwa ndi dziko lonse malamulo ndi ndondomeko zosiyanasiyana.Kuyambira 2012 mpaka 2018, linanena bungwe la China mankhwala intermediates makampani chinawonjezeka kuchokera pafupifupi matani 8.1 miliyoni ndi kukula msika pafupifupi 168.8 biliyoni yuan pafupifupi 10.12 miliyoni matani ndi kukula msika wa 2017 biliyoni yuan.China mankhwala mankhwala. intermediates makampani akwaniritsa kupikisana amphamvu mu msika, ndipo ngakhale ena opanga intermediates atha kutulutsa intermediates ndi dongosolo zovuta maselo ndi zofunika mkulu luso. Zinthu zambiri zodziwika bwino zayamba kulamulira msika wapadziko lonse lapansi. makampani opanga mankhwala apakati akadali oyambira mankhwala apakatikati, pomwe kuchuluka kwapakati pazamankhwala apamwamba komanso othandizira apakati pamankhwala atsopano ovomerezeka ndi osowa.