Chidule: acetone inayambitsa chloride ndipo imapangidwa ndi solvent crystallization pa 1,1,3-trichloroacetone yokhala ndi chiyero chachikulu chosachepera 99.0%, yokhala ndi phindu la 45% o Mawu ofunikira: 1,1,3-trichloroacetone; kupanga; chiyero chachikulu

———-. Mawu Oyamba

1,1,3■trichloroacetone ndi gawo lofunika kwambiri pakupanga folic acid. Pakadali pano, 1,1,3.acetone trichloropacetone, nthawi yayitali yopangira (maola 48), kusankha kosayenera, zokolola zochepa, 1,1,3-trichloropacetone kuchuluka ndi pafupifupi 17% yokha, pambuyo pochotsa madzi, kuchuluka kwake ndi 51.9% yokha. Ndipo mtengo wopangira ndi wokwera, kukonza kwa mankhwalawa ndi kochepa. Zonsezi zimapangitsa kuti pakhale ndalama zambiri zopangira folic acid m'nyumba, zovuta kukonza zomwe zili mkati mwake ndi mavuto ena. Wolembayo adawerenga zikalata zambiri zamkati ndi zakunja. Pambuyo pa kuyesa ndi maphunziro ambiri, tidawonjezera catalyst ndi controlled fou chlorine speed, kuchepetsa nthawi yochitira zinthu kufika pa 1,1,3-3 trichloropacetone mu maola 24, ndi 1,1,3-3 trichloropacetone crystallization yokhala ndi chiyero choposa 99% ndipo zokolola zake ndi zoposa 45%.

II. Gawo loyesera

1. kuchitapo kanthu

0 0 0 0

1. II.

　　CHACCHa+Cl:—ClCH.₂CCH.₃+Cl.₂CHCCH.₃+C1CH.₂CCH.₂C1+

1. Masitepe oyesera

Mu botolo la khosi zinayi lokhala ndi condenser yozungulira ya 500ml, kuchuluka kwa acetone ndi catalyst kunasunthidwa ndikuperekedwa ku chlorine pa kutentha kwa reaction ya 10 ~ 30 W. Yambani nthawi, siyani kudutsa mu chlorine maola angapo mutachita reaction, ndipo pitirizani kusakaniza kwa ola limodzi. Chosungunulira chapadera chinawonjezedwa ku chisakanizocho, chinasunthidwa kwa ola limodzi pamene chinazizira mpaka 10°C crystallization, ndikutulutsa 1,1,3-trichloroacetone.

1. 1,1,3. Kutsimikiza kosankha kwa kuyera kwa trichloroacetone

Chromatograph ya gasi ya Varin 3700, QF・mzati wodzaza 1 ndi chowunikira cha FID zidagwiritsidwa ntchito posankha phindu la kuyera kwa chinthucho ndi yankho la chloride.

1. Zotsatira za zokambiranazo
2. Mphamvu ya catalyst pa kusankha kwa chloride yawonetsa kusankha kwa acetone chlorination.

Mphamvu yayikulu, Gome 1 ikuwonetsa zotsatira zoyeserera. Kuchokera pa Gome 1, kusankha kochepa kwa 1,1,3-trichloroacetone kumawonjezeka kwambiri (pafupifupi 19.1%) popanda chothandizira, ndipo

　　Chothandizira cha amine chophatikizika ndicho chabwino kwambiri, mpaka 57.5% o. Mikhalidwe yoyesera: Innl acetone, 3nr) l chlorine, chothandizira 0.6g, kutentha 1030°C,

nthawi maola 18. Mkati mwa maola 12 va:3.9 Cao h;2

〜Maola 7, vq:27 Cao h;7〜Maola 18, VQ:3.9 mpaka h.Table 1. Zotsatira za chothandizira pa kusankha kwa chinthu

1. Zotsatira za liwiro la through-chlorine pa reaction

Kuyeseraku kunapeza kuti chlorine yofanana inali ndi kusankha kosayenera kwa zinthu, zomwe zinapangitsa kuti kusankha ndi kukolola kwa zinthuzo kukhale kothandiza kwambiri.

Gome 2 likuwonetsa deta yoyesera.

Gome 2 Zotsatira za liwiro la pass-chlorine pa kusankha kwa mankhwala

Mayeso^mkhalidwe:]Petri mbale 1 acetone, chothandizira: gulu lophatikiza 0.6go

Kuyeseraku kunapeza kuti fluchlorine inali yoyambirira (maola 12) ndipo pambuyo pake (maola 8 mpaka 24), chlorine yambiri imatuluka kuti yankho lake linali lochedwa ndipo lapakati (maola 28) linali lachangu. Mpweya wa chlorine ukayimitsidwa, kusankha kwa mankhwala ndi zokolola zake kumachepa kwambiri. Zotsatira zake zinasonyeza kuti 1,1,3 inapanga pang'onopang'ono kwambiri kuposa

1,1-dichloroacetone. Pa nthawi ya kuyankha ndi

kloridi, kloridi, acetone, 1,1,4003000,

CICH2CCH3

o.

zimenezo ndi_II.Kuchuluka kwa chlorination pa gulu la submethyl kunali kwakukulu.

mofulumira kuposa gulu la methyl. Chifukwa chake,

Wolembayo akukhulupirira kuti njira yopangira acetone chloride ndi:

Yankho limachitika ndi V1 1 2-5 ngati njira yayikulu.

Malinga ndi deta ya Table 2, dongosolo la liwiro la reaction la sitepe iliyonse ndi

　　V2^”3^1 2 5>V4

Kutengera ndi liwiro la kuchitapo kanthu pa sitepe iliyonse,

Zikuoneka kuchokera mu deta ya Table 3 kuti, chifukwa cha kusiyana pang'ono kwa kutentha pakati pa 1, 1, 3. trichloroacetone ndi zinthu zina, nthawi zambiri zimakhala zovuta kulekanitsa kutulutsa madzi ndipo kulekanitsa ndi njira yosavuta. Ngakhale kuti zinthu zambiri za I zimatha kuchotsedwa, kuyera kwake kumakhala kovuta.

Timawongolera liwiro la chlorine pa gawo lililonse,

kuti akwaniritse cholinga chochepetsa nthawi yodutsa ya chlorine ndikuletsa kusankha kowonjezera liwiro lachiwiri la reaction ndi 1,1,3 trichloroacetone.

1. Kuyeretsa makristalo kothira madzi Malinga ndi mabuku, nthawi zambiri

Madzi a acetone chloride amachotsedwa kapena kuyengedwa ndi madzi kuti awonjezere kuchuluka kwa 1,1,3-trichloroacetone, ndipo wolembayo adagwiritsa ntchito 1,1,3-trichloroacetone kuti apange makristalo kuchokera ku zinthu zina.

Gome 3 limatchula kuyera kwa chinthu chomwe chimapezeka pogwiritsa ntchito njira zosiyanasiyana zolekanitsira.

Gome 3. Kuyera kwa zinthu komwe kumapezeka kuchokera ku njira zosiyanasiyana zolekanitsira

kuti zinthu ziwongolere bwino. Kuyera kwa malonda kumafika pa 99%, ndipo zokolola zake zimakhala zapamwamba kwambiri m'njira zingapo, mpaka 45%. Njirayi imafuna kuchuluka kwa 1,1,3-trichloroacetone ya K yoposa 50% mu yankho la chloride.

Sankhani chothandizira cha amine choyenera, chepetsani kutsekeka kwa chlorine pang'onopang'ono kumayambiriro ndi kumapeto kwa 10 ~ 30°C, ikhoza kupanga 1,1,3-trichloroacetone chloride, yoyeretsedwa ndi crystallization yapadera ya solvent, kupeza chinthu cha crystalline chosachepera 99.0%, ndi zokolola za 45%, koma 1,1,3-trichloroacetone mu yankho la chloride iyenera kukhala yoposa 50%o.CEO wa Athena

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